Systemic Lupus Erythematosus ( Sle ) - 1591 Words

Systemic Lupus Erythematosus Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple tissues and systems and with significant variable clinical features and organ involvement (Cava, 2010). It is characterized by a chronic, relapsing, inflammatory and often febrile multisystemic disorder of connective tissue with wide spectrum of involvement of skin, joints, kidneys and serosal membranes. The exact etiology is noknown, but it represents failure of the regulatory mechanisms of immune system in which body s own defenses are turned against themselves (Edworthy, 2005##########). It has a worldwide distribution with unpredictable course of flares and remissions, where a cumulative damage over time significantly†¦show more content†¦The disease is milder and survival is higher among persons with isolated cutaneous and musculoskeletal disease than in those with renal and CNS involvement. the most frequent causes of death in SLE patients are Infections and diseases of the cardiovascular, renal, pulmonary, and central nervous systems (Bartels et al., 2012). In spite of the improvement of the survival rate, patients with SLE still have a higher death rate (3-5 times) than that of general population (Schur, 2001). B. Etiology: The definite pathologic mechanisms of SLE remain elusive, and the etiology of SLE is known to be multi-factorial, involving genetic, hormonal, and environmental factors. Environmental triggers with susceptible genetic background, act on the immune system to initiate autoimmunity (Tiffin et al., 2013). 1- Genetic factors: There is a clear genetic component in SLE, with a sibling risk ratio 8- 29 folds higher than that in the general population and a 10 folds increase in disease concordance in identical twins. In addition, there is a 24-56% concordance rate in monozygotic twins, compared with a 2-5% risk in dizygotic twins (Deng and Tsao, 2010). Many genes that may contribute to lupus have been identified by means of whole-genome scans from families in whom multiple members have SLE (Namjou et al., 2007). The genes associatedShow MoreRelatedSystemic Lupus Erythematosus ( Sle )1689 Words   |  7 Pagesare threatening to the mankind. Systemic lupus erythematosus (SLE) is a classic example of such a disease. SLE is a chronic, often life-long, autoimmune condition, ranging from mild to severe in severity. SLE may affect many organs in the body, including but not limited to kidneys, skin, joints, respiratory and nervous systems. The name of this disease describes it; word systemic indicates the widespread involvement of various tissues and organs of the body. Lupus is a word derived from Latin languageRead MoreSystemic Lupus Erythematosus ( Sle ) As Simply Lupus1604 Words   |  7 PagesAbstract Most know Systemic Lupus Erythematosus (SLE) as simply lupus. It is difficult to diagnose and treat but the symptoms can be mentally and physically devastating for any patient. Many may not realize the extent to which a person with SLE is affected on a day to day basis. It is important for healthcare professionals to understand the disease process, including the cause, signs, symptoms, and treatment of SLE. By understanding the aforementioned, healthcare professionals can assist with reportingRead MoreSystemic Lupus Erythematosus ( Sle )1780 Words   |  8 Pages(LN) Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, immune-complex-mediated multi-systemic autoimmune condition of multifactorial etiology (Mak and Tay 2014). LN is an inflammatory condition affecting the kidneys which is caused by SLE, an autoimmune disease that is more common among women. About half of all people with SLE develop lupus nephritis, and of these about 1/10 experience chronic kidney disease or kidney failure (Henderson et al. 2012). Epidemiology of Lupus nephritis:Read MoreSystemic Lupus Erythematosus And Its Effects On The Body s Own Immune System2633 Words   |  11 Pages Systemic Lupus Erythematosus, or Erythematous, also known as SLE, is a chronic inflammatory, autoimmune disease that transpires when the body’s own immune system assaults, with â€Å"variable manifestations†, it’s own tissues and organ systems throughout the itself1,2,3. This can also include joints, heart, lungs, skin, brain, blood cells, etc1. Systemic Lupus Erythematosus is known to have an impact on the organ network involved with immune complexes and multiple antibodies, especially antinuclearRead MoreLupus : An Autoimmune Disease3344 Words   |  14 PagesWhat is Lupus? Lupus is an autoimmune disease in which our autoantibodies target self-proteins, known as ANAs. Systemic Lupus Erythematosus (SLE) is understood to be caused by our genetics and the environmental triggers from our everyday lives. There are four different types to this incurable but manageable disease, Cutaneous Lupus Erythematosus, Drug-induced Lupus Erythematosus, Neonatal Lupus, and Systemic Lupus Erythematosus. I will cover all of them, the main focus is on Systemic Lupus ErythematosusRead MoreSystemic Lupus Erythmatosus Essay example1364 Words   |  6 PagesLupus is a chronic inflammatory disease that occurs when your body’s immune system attacks your own tissues and organs. The inflammation caused by lupus can affect many body systems including the following: joints, skin, kidneys, blood cells, heart and lungs. Lupus occurs more frequently in women than in men. There are four different types of Lupus that exist. They are Systemic lupus erythematosus, Discoid lupus erythematosus, Drug-induced erythematosus, and Neonatal lupus. The most common andRead MoreThe Pathogenesis Associated With Sle2382 Words   |  10 Pagesassociated with SLE is complex and attributed to various factors. These factors include sex, the imbalance of hormones, and ones’ hypothalamus, pituitary, and adrenal axes. Others have said that it is attributed to the cells in your body that are dying, over active help of the T cells in the body, defective B cells, and the shifting of the T helper 1(Th1) to T helper 2 (Th2), which are responsible for the B cells causing   them to produce these pathogenic antibodies that cause SLE. (Cambridge, TeodorescuRead MoreSymptoms And Treatment Of Systemic Lupus Erythematosus1183 Words   |  5 PagesPSYCHOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS: A REVIEW Abstract Key words – Lupus, Psychosis, SLE, NP SLE, steroids, reversible INTRODUCTION Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease of multifactorial etiology that can affect many organs and systems (Sato, 2002). The studies show a higher prevalence in women (approximately 90% of cases), especially during childbearing years, i.e. between 15 and 45 years of age; more common in women of black ethnicity thanRead More Systemic Lupus Essay1613 Words   |  7 Pages Systemic lupus erythematosus (SLE) is a fairly common disease identified as episodes of inflammation and damage to joints, tendons, and various organs. The most effected organs are the heart, lungs, brain, kidneys, blood vessels, and skin. Lupus affects each individual differently and the effects could be mild to severe depending on the individual. SLE is an autoimmune disease where the body’s immune system attacks the healthy cells and tissues in the body (Ohio State, 2009). The main cause ofRead MoreClinical Pathology : Systemic Lupus Erythematosus8402 Words   |  34 PagesZagazig University Faculty of Medicine Clinical Pathology Department Association of STAT4 Gene Single-nucleotide Polymorphism with Systemic Lupus Erythematosus Thesis Submitted for partial fulfillment of M.D. degree in clinical pathology By Marwa Abd El-Monem Mohamed Ateya MB.B.CH. Ass .lecturer of Clinical Pathology Faculty of Medicine Zagazig University Prof. Dr. Lamiaa Abd Al-wahab Mohammad Professor of Clinical Pathology Faculty of Medicine Zagazig University Prof. Dr. Asmaa